By Priv.-Doz. Dr. med. Rainer Haas, Dr. med. Ralf Kronenwett, Priv.-Doz. Dr. rer. nat. Georg Sczakiel (auth.)

This booklet offers an summary of the present cutting-edge in peripheral blood stem cellphone transplantation and up to date advancements in molecular analysis and gene healing techniques. the focal point is at the function of peripheral blood stem telephone transplantation within the therapy of hematological malignancies similar to non-Hodgkin lymphomas, persistent myelogenous leukemia and a number of myeloma. present molecular organic thoughts for detecting genetic defects in tumors and minimum residual affliction also are provided. extra subject matters contain new gene healing options in hematology and oncology: using viral vectors for transduction of hematopoietic cells is mentioned in addition to healing techniques in keeping with antisense nucleic acids, ribozymes, and immunological approaches.

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1, while the nonhematological toxicity is shown in Table 2. More days with fever and antibiotic as well as antimycotic treatment were observed after TBI. In the TBI group, significantly longer periods of parenteral nutrition were also necessary due to severe mucositis. :! ~ .... ::: ::: e (J 100 95 90 85 80 75 70 65 60 55 50 2 patients with detayed platelet reconstitution (59 and 157 days) Platelets - PMN 45 40 35 30 25 20 15 10 5 0 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 Reconstitution after PBPer in Days Fig.

Molecular methods may offer some advantages for monitoring patients with CML. Quantitative Southern blot, quantitative FISH, quantitative western blot, and competitive RT-PCR can be performed on peripheral blood specimens and are therefore less invasive than conventional cytogenetic analysis of bone marrow. Furthermore, these techniques are applicable to Ph-negative/BCR-ABL-positive cases. We have shown that BCR-ABL transcript numberS/fig RNA and BCR-ABL/ ABL ratios correlate with the cytogenetic response.

In rare instances, however, Southern blot analysis is negative due to breakpoints outside M-bcr or mutations of the affected BCR allele (Bartram et al. 1987; Saglio et al. 1990; Pane et al. 1996; Hochhaus et al. 1996a; Melo 1996). Using densitometry of the autoradiograph signals, Southern blot facilitates quantification of the proportion of cells, out of all cells investigated, that carry a BCR rearrangement. The "BCR ratio" has been established to express this proportion: [BCR ratio = (2xrearranged signals)/(rearranged+germline signals)].

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